21 Elegant Collagen Basement Membrane

collagen basement membrane ncbi nlm nih gov Am J Pathol v 168 3 2006 MarThe major component of the basement membrane is known to be type IV collagen 1 Nevertheless a precise role for type IV collagen in its assembled suprastructural form versus its unassembled degraded form is primarily unknown collagen basement membrane membraneThe basement membrane is composed of different extracellular matrix structural proteins e g collagen laminin In addition embedded into the basement membrane are several important receptors e g integrins which play a key role in mediating endothelial signaling cell migration and brain capillary tube formation during angiogenic responses

dev biologists content 131 7 1619Taken together with other basement membrane protein knockouts these data suggest that laminin is sufficient for basement membrane like matrices during early development but at later stages the specific composition of components including collagen IV defines integrity stability and functionality collagen basement membrane structure and immunochemistry of the interstitial collagens types I II and III and the structure of basement membrane collagen type IV and filamentous collagen type VI are described jbc content 275 39 30716 fullThe ultrafiltration function of the glomerular basement membrane GBM of the kidney is impaired in genetic and acquired diseases that affect type IV collagen The GBM is composed of five 1 to 5 of the six chains of type IV collagen organized into an 1 2 IV and an 3 4 5 IV network Published in Journal of Biological Chemistry 2000Authors Ariel Boutaud Dorinbogdan Borza Olga Bondar Sripad Gunwar Kaiolaf Netzer N Affiliation University of KansasAbout Glomerular basement membrane Type IV collagen

glomerular basement membrane GBM of the kidney is the basal lamina layer of the glomerulus The glomerular endothelial cells become inflamed as a result of damage to the basement membrane by antibodies to alpha 3 NC1 domain of type IV collagen FMA 74274MeSH D050533Layers Pathology collagen basement membrane jbc content 275 39 30716 fullThe ultrafiltration function of the glomerular basement membrane GBM of the kidney is impaired in genetic and acquired diseases that affect type IV collagen The GBM is composed of five 1 to 5 of the six chains of type IV collagen organized into an 1 2 IV and an 3 4 5 IV network Published in Journal of Biological Chemistry 2000Authors Ariel Boutaud Dorinbogdan Borza Olga Bondar Sripad Gunwar Kaiolaf Netzer N Affiliation University of KansasAbout Glomerular basement membrane Type IV collagen dictionary thefreedictionary basement membranebasement membrane An organised multi molecular extracellular matrix composed of collagens predominantly type IV glycoproteins e g laminin fibronectin and proteoglycans e g dermatan sulfate which is characteristically found under epithelial and endothelial cells