21 Images Glomerular Basement Membrane Function

glomerular basement membrane function ncbi nlm nih gov Journal List HHS Author ManuscriptsMay 15 2012 The glomerular basement membrane GBM is the extracellular matrix component of the selectively permeable glomerular filtration barrier GFB that glomerular basement membrane function basement membraneThe glomerular basement membrane GBM is formed at the boundary of the basal laminas of the podocytes of the glomerulus and the endothelial cells of renal capillaries

jbc content 273 15 8767 longApr 10 1998 Abstract Glomerular basement membrane GBM plays a crucial function in the ultrafiltration of blood plasma by the kidney This function is impaired in Alport syndrome a hereditary disorder that is caused by mutations in the gene encoding type IV collagen but it is not known how the mutations lead to a defective GBM Published in Journal of Biological Chemistry 1998Authors Sripad Gunwar Fernando Ballester Milton E Noelken Yoshikazu Sado Yoshifumi Affiliation University of KansasAbout Alport syndrome Glomerular basement membrane Type IV collagen glomerular basement membrane function unckidneycenter Kidney Health Library Glomerular DiseaseThe only abnormal finding in this disease is a thinning of the basement membrane of the glomeruli filters in the kidneys Most patients with TBM disease maintain normal kidney function physiology glomerular filtrationFigure of glomerular capillary wall consisting of the endothelium basement membrane and epithelium Together the glomerulus and glomerular capsule filtering unit are known as a renal corpuscle Figure of a renal corpuscle

15 2012 The glomerular basement membrane GBM is the extracellular matrix component of the selectively permeable glomerular filtration barrier GFB that glomerular basement membrane function physiology glomerular filtrationFigure of glomerular capillary wall consisting of the endothelium basement membrane and epithelium Together the glomerulus and glomerular capsule filtering unit are known as a renal corpuscle Figure of a renal corpuscle 09 2015 The glomerular basement membrane GBM is the vital barrier between blood and glomerular filtrate Diseases that damage it generally cause haematuria initially but as architecture becomes disordered proteinuria becomes an increasing feature