19 Lovely Kidney Basement Membrane

kidney basement membrane glomerular basement membrane GBM of the kidney is the basal lamina layer of the glomerulus The glomerular endothelial cells the GBM and the filtration slits between the podocytes perform the filtration function of the glomerulus separating the blood in the capillaries from the FMA 74274MeSH D050533Layers Pathology kidney basement membrane unckidneycenter Kidney Health Library Glomerular DiseaseTBM disease also known as benign familial hematuria and thin basement membrane nephropathy is along with IgA nephropathy the most common cause of blood in the urine without any other symptoms The only abnormal finding in this disease is a thinning of

glomerular basement membrane GBM mostly contains 345 which is also present in the eye ear and lungs 556 is found in skin basement membrane and parts of the gut Tissue specific collagen and laminin isoforms replace generic forms during kidney development kidney basement membrane basement membraneKidney Glomerular Basement Membrane Embryonic Index Kid GBM The glomerular basement membrane GBM is formed at the boundary of the basal laminas of the podocytes of the glomerulus and the endothelial cells of renal capillaries It is an acellular extracellular matrix layer organized into three sublayers the lamina densa lamina rara membrane function The basement membrane lies between the epidermis or outer layer of skin and the dermis the middle layer of skin keeping them tightly connected But basement membranes aren t just found in the

ncbi nlm nih gov Journal List HHS Author ManuscriptsMay 15 2012 The kidney s glomerular filtration barrier consists of two cells podocytes and endothelial cells and the glomerular basement membrane GBM a specialized extracellular matrix that lies between them Like all basement membranes the GBM consists mainly of laminin type IV collagen nidogen and heparan sulfate proteoglycan kidney basement membrane membrane function The basement membrane lies between the epidermis or outer layer of skin and the dermis the middle layer of skin keeping them tightly connected But basement membranes aren t just found in the edren pages edreninfo glomerular basement membrane Deterioration to kidney failure is common Other diseases affecting the GBM The GBM is thickened with normal basement membrane material in two common kidney disease membranous nephropathy and diabetic nephropathy kidney disease caused by diabetes Follow the links for further information