19 Unique Thin Basement Membrane Syndrome

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thin basement membrane syndrome basement membrane diseaseThin basement membrane disease TBMD is an inherited disorder that mainly affects the glomeruli which are tiny tufts of capillaries small blood vessels in the kidneys that filter wastes from the blood It is a rare disorder that has been diagnosed in less than 1 percent of the population thin basement membrane syndrome ncbi nlm nih gov J Clin Pathol v 40 3 1987 MarRenal symptoms were found in four families although no relative had Alport s syndrome Renal biopsy findings observed by light and immunofluorescence microscopy did not indicate any important abnormalities but extensive diffuse thinning of the glomerular basement membrane ranging from 153 to 213 nm was a constant finding by electron microscopy

basement membrane nephropathy TBMN is the most common cause of persistent hematuria in children and adults the other main causes being IgA nephropathy and Alport syndrome 1 3 In addition to hematuria patients with TBMN usually have minimal proteinuria normal renal function and uniformly thinned glomerular basement membranes GBM thin basement membrane syndrome basement membrane diseaseTHIN GLOMERULAR BASEMENT MEMBRANE DISEASE Thin GBM disease also known as benign familial hematuria describes a condition that differs from Alport disease in its benign course and lack of progression The true incidence of thin GBM disease is unknown reports evaluating patients with isolated hematuria suggest that 20 to 25 of such patients have thin GBM disease disease may be As a small proportion of children initially diagnosed with thin basement membrane disease eventually receive an Alport disease diagnosis it is crucial to continue to monitor all children with thin basement membranes performing genetic and tissue analyses as often as possible

diet for a person with thin Although thin basement membrane disease sounds like something that would affect the lower levels of your house it s actually an often inherited disorder that affects the kidneys This disorder also called benign familial hematuria affects between 5 and 9 percent of Americans according to the Merck Manual thin basement membrane syndrome disease may be As a small proportion of children initially diagnosed with thin basement membrane disease eventually receive an Alport disease diagnosis it is crucial to continue to monitor all children with thin basement membranes performing genetic and tissue analyses as often as possible basement membrane Thin basement membrane nephropathy TBMN also called thin basement membrane disease is considered a relatively common disorder In most patients the only abnormal finding on renal biopsy is diffuse thinning of the glomerular basement membranes GBM requiring electron microscopy for the diagnosis 1 4