19 Unique Basement Membrane Kidney

basement membrane kidney basement membrane diseaseThin basement membrane disease TBMD is an inherited disorder that mainly affects the glomeruli which are tiny tufts of capillaries small blood vessels in the kidneys that filter wastes from the blood It is a rare disorder that has been diagnosed in less than 1 percent of the population basement membrane kidney unckidneycenter Kidney Health Library Glomerular DiseaseTBM disease also known as benign familial hematuria and thin basement membrane nephropathy is along with IgA nephropathy the most common cause of blood in the urine without any other symptoms The only abnormal finding in this disease is a thinning of

basement membraneThe glomerular basement membrane GBM is formed at the boundary of the basal laminas of the podocytes of the glomerulus and the endothelial cells of renal capillaries basement membrane kidney glomerular basement membrane GBM is the vital barrier between blood and glomerular filtrate Diseases that damage it generally cause haematuria initially but as architecture becomes disordered proteinuria becomes an increasing feature

ncbi nlm nih gov Journal List HHS Author ManuscriptsMay 15 2012 The kidney s glomerular filtration barrier consists of two cells podocytes and endothelial cells and the glomerular basement membrane GBM a specialized extracellular matrix that lies between them Like all basement membranes the GBM consists mainly of laminin type IV collagen nidogen and heparan sulfate proteoglycan basement membrane kidney